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Resveratrol

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6.  Zamora-Ros R, et al Concentrations of resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population: European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort . Br J Nutr. (2008)

7.  Delmas D, et al Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer . Curr Drug Targets. (2006)

8.  Timperio AM, et al Production of the phytoalexins trans-resveratrol and delta-viniferin in two economy-relevant grape cultivars upon infection with Botrytis cinerea in field conditions . Plant Physiol Biochem. (2012)

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12.  Huang X, Mazza G Simultaneous analysis of serotonin, melatonin, piceid and resveratrol in fruits using liquid chromatography tandem mass spectrometry . J Chromatogr A. (2011)

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16.  Rius C, et al Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation . J Immunol. (2010)

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18.  Orallo F Comparative studies of the antioxidant effects of cis- and trans-resveratrol . Curr Med Chem. (2006)

19.  Leiro J, et al Effects of cis-resveratrol on inflammatory murine macrophages: antioxidant activity and down-regulation of inflammatory genes . J Leukoc Biol. (2004)

20.  Fabbrocini G, et al Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study . Am J Clin Dermatol. (2011)

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28.  Kelly G A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1 . Altern Med Rev. (2010)

29.  Kelly GS A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 2 . Altern Med Rev. (2010)

30.  Agarwal B, Baur JA Resveratrol and life extension . Ann N Y Acad Sci. (2011)

31.  Howitz KT, et al Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan . Nature. (2003)

32.  Kaeberlein M, et al Substrate-specific activation of sirtuins by resveratrol . J Biol Chem. (2005)

33.  Pacholec M, et al SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1 . J Biol Chem. (2010)

34.  Beher D, et al Resveratrol is not a direct activator of SIRT1 enzyme activity . Chem Biol Drug Des. (2009)

35.  SIRT1 activation by small molecules - kinetic and biophysical evidence for direct interaction of enzyme and activator

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37.  AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

38.  Park CE, et al Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase . Exp Mol Med. (2007)

39.  Resveratrol stimulates AMP kinase activity in neurons

40.  Cantó C, et al AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity . Nature. (2009)

41.  Price NL, et al SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function . Cell Metab. (2012)

42.  Lan F, et al SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation . J Biol Chem. (2008)

43.  Hou X, et al SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase . J Biol Chem. (2008)

44.  Park SJ, et al Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases . Cell. (2012)

45.  Feige JN, et al Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation . Cell Metab. (2008)

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51.  Walle T, et al High absorption but very low bioavailability of oral resveratrol in humans . Drug Metab Dispos. (2004)

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56.  Metabolism and Disposition of Resveratrol in Rats: Extent of Absorption, Glucuronidation, and Enterohepatic Recirculation Evidenced by a Linked-Rat Model

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58.  Vaz-da-Silva M, et al Effect of food on the pharmacokinetic profile of trans-resveratrol . Int J Clin Pharmacol Ther. (2008)

59.  la Porte C, et al Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects . Clin Pharmacokinet. (2010)

60.  De Santi C, et al Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum . Xenobiotica. (2000)

61.  Soleas GJ, Yan J, Goldberg DM Measurement of trans-resveratrol, (+)-catechin, and quercetin in rat and human blood and urine by gas chromatography with mass selective detection . Methods Enzymol. (2001)

62.  Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection

63.  Smoliga JM, Baur JA, Hausenblas HA Resveratrol and health--a comprehensive review of human clinical trials . Mol Nutr Food Res. (2011)

64.  De Santi C, et al Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids . Xenobiotica. (2000)

65.  Pacifici GM Inhibition of human liver and duodenum sulfotransferases by drugs and dietary chemicals: a review of the literature . Int J Clin Pharmacol Ther. (2004)

66.  Boocock DJ, et al Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent . Cancer Epidemiol Biomarkers Prev. (2007)

67.  Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study

68.  Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

69.  Brown VA, et al Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis . Cancer Res. (2010)

70.  Goldberg DM, Yan J, Soleas GJ Absorption of three wine-related polyphenols in three different matrices by healthy subjects . Clin Biochem. (2003)

71.  Gresele P, et al Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production . J Nutr. (2008)

72.  Soleas GJ, Yan J, Goldberg DM Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection . J Chromatogr B Biomed Sci Appl. (2001)

73.  Wenzel E, Somoza V Metabolism and bioavailability of trans-resveratrol . Mol Nutr Food Res. (2005)

74.  A Global Survey of Trans-Resveratrol Concentrations in Commercial Wines

75.  Wu JM, Hsieh TC, Wang Z Cardioprotection by resveratrol: a review of effects/targets in cultured cells and animal tissues . Am J Cardiovasc Dis. (2011)

76.  Khan MA, Muzammil S, Musarrat J Differential binding of tetracyclines with serum albumin and induced structural alterations in drug-bound protein . Int J Biol Macromol. (2002)

77.  Jannin B, et al Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake . Biochem Pharmacol. (2004)

78.  Belguendouz L, Frémont L, Gozzelino MT Interaction of transresveratrol with plasma lipoproteins . Biochem Pharmacol. (1998)

79.  Curry S, Brick P, Franks NP Fatty acid binding to human serum albumin: new insights from crystallographic studies . Biochim Biophys Acta. (1999)

80.  Lançon A, et al Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process . Biochem Biophys Res Commun. (2004)

81.  Wang Q, et al Resveratrol protects against global cerebral ischemic injury in gerbils . Brain Res. (2002)

82.  Bertelli A, et al Plasma and tissue resveratrol concentrations and pharmacological activity . Drugs Exp Clin Res. (1998)

83.  Vitrac X, et al Distribution of (14C)-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration . Life Sci. (2003)

84.  Camont L, et al Radical-induced oxidation of trans-resveratrol . Biochimie. (2012)

85.  Bass TM, et al Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans . Mech Ageing Dev. (2007)

86.  Wang C, et al The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster . Age (Dordr). (2011)

87.  Bauer JH, et al Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling . Proc Natl Acad Sci U S A. (2007)

88.  Bauer JH, et al dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster . Aging (Albany NY). (2009)

89.  Antosh M, et al Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila . Cell Cycle. (2011)

90.  Flatt T, Tu MP, Tatar M Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history . Bioessays. (2005)

91.  Chandrashekara KT, Shakarad MN Aloe vera or resveratrol supplementation in larval diet delays adult aging in the fruit fly, Drosophila melanogaster . J Gerontol A Biol Sci Med Sci. (2011)

92.  Frankel S, Ziafazeli T, Rogina B dSir2 and longevity in Drosophila . Exp Gerontol. (2011)

93.  Labbé A, et al Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome . J Gerontol A Biol Sci Med Sci. (2011)

94.  Miller RA, et al Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice . J Gerontol A Biol Sci Med Sci. (2011)

95.  Pearson KJ, et al Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span . Cell Metab. (2008)

96.  Barger JL, et al A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice . PLoS One. (2008)

97.  Baur JA, et al Resveratrol improves health and survival of mice on a high-calorie diet . Nature. (2006)

98.  Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation

99.  Chang Y, Wang SJ Inhibitory effect of glutamate release from rat cerebrocortical nerve terminals by resveratrol . Neurochem Int. (2009)

100.  Gao ZB, Chen XQ, Hu GY Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus . Brain Res. (2006)

101.  Li M, et al Resveratrol inhibits neuronal discharges in rat hippocampal CA1 area . Sheng Li Xue Bao. (2005)

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104.  Zhang LP, et al Effect of resveratrol on L-type calcium current in rat ventricular myocytes . Acta Pharmacol Sin. (2006)

105.  Moldzio R, et al Protective effects of resveratrol on glutamate-induced damages in murine brain cultures . J Neural Transm. (2013)

106.  Lee JG, et al Combined treatment with capsaicin and resveratrol enhances neuroprotection against glutamate-induced toxicity in mouse cerebral cortical neurons. Food Chem Toxicol. (2012)

107.  Saleh MC, Connell BJ, Saleh TM Resveratrol preconditioning induces cellular stress proteins and is mediated via NMDA and estrogen receptors . Neuroscience. (2010)

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110.  Wang Q, et al Resveratrol protects against neurotoxicity induced by kainic acid . Neurochem Res. (2004)

111.  Gupta YK, Briyal S, Chaudhary G Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats . Pharmacol Biochem Behav. (2002)

112.  Shetty AK Promise of resveratrol for easing status epilepticus and epilepsy . Pharmacol Ther. (2011)

113.  Wu Z, et al Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats . Neurochem Res. (2009)

114.  Friedman LK, et al Lack of resveratrol neuroprotection in developing rats treated with kainic acid . Neuroscience. (2013)

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118.  Tsai RY, et al Resveratrol regulates N-methyl-D-aspartate receptor expression and suppresses neuroinflammation in morphine-tolerant rats . Anesth Analg. (2012)

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127.  Quincozes-Santos A, Gottfried C Resveratrol modulates astroglial functions: neuroprotective hypothesis . Ann N Y Acad Sci. (2011)

128.  dos Santos AQ, et al Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells . Arch Biochem Biophys. (2006)

129.  de Almeida LM, et al Resveratrol increases glutamate uptake, glutathione content, and S100B secretion in cortical astrocyte cultures . Cell Mol Neurobiol. (2007)

130.  Bobermin LD, et al Resveratrol prevents ammonia toxicity in astroglial cells . PLoS One. (2012)

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134.  Kwon KJ, et al Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways . J Clin Neurol. (2010)

135.  Kwon KJ, et al Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection . J Pineal Res. (2011)

136.  Porquet D, et al Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8 . Age (Dordr). (2012)

137.  Kao CL, et al Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation . J Atheroscler Thromb. (2010)

138.  Zou J, et al Effects of resveratrol on oxidative modification of human low density lipoprotein . Chin Med J (Engl). (2000)

139.  Zou JG, et al Resveratrol inhibits copper ion-induced and azo compound-initiated oxidative modification of human low density lipoprotein . Biochem Mol Biol Int. (1999)

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146.  Spanier G, et al Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4) . J Physiol Pharmacol. (2009)

147.  Xia N, et al Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice . J Pharmacol Exp Ther. (2010)

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150.  Resveratrol Increases Nitric Oxide Synthase, Induces Accumulation of p53 and p21WAF1/CIP1, and Suppresses Cultured Bovine Pulmonary Artery EndothelialCell Proliferation by Perturbing Progression through S and G2

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154.  Mizutani K, et al Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats . J Nutr Sci Vitaminol (Tokyo). (2000)

155.  Wang Z, et al Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts .Biochem Biophys Res Commun. (2006)

156.  Dealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide

157.  Hsieh TC, et al Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53 . Biochem Biophys Res Commun. (2005)

158.  Wang Z, et al Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography . Biochem Biophys Res Commun. (2004)

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160.  de Gaetano G, et al Antithrombotic effect of polyphenols in experimental models: a mechanism of reduced vascular risk by moderate wine consumption . Ann N Y Acad Sci. (2002)

161.  Timmers S, et al Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans . Cell Metab. (2011)

162.  Brasnyó P, et al Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients . Br J Nutr. (2011)

163.  Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

164.  Ku CR, et al Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic β-cell and the cleavage of poly (ADP-ribose) polymerase . Endocr J. (2012)

165.  Zhang J, et al The protective effect of resveratrol on islet insulin secretion and morphology in mice on a high-fat diet . Diabetes Res Clin Pract. (2012)

166.  Minakawa M, et al Hypoglycemic effect of resveratrol in type 2 diabetic model db/db mice and its actions in cultured L6 myotubes and RIN-5F pancreatic β-cells .J Clin Biochem Nutr. (2011)

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171.  Rayalam S, et al Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes . Phytother Res. (2008)

172.  Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes

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175.  Fischer-Posovszky P, et al Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner . Am J Clin Nutr. (2010)

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177.  Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

178.  AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

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